Rotigotine (b)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

罗替高汀是一种抗帕金森病药和多巴胺受体激动剂。

Rotigotine is an antiparkinson agent and dopamine receptor agonist.

Rotigotine has a 10-fold selectivity for D3 (pKi=9.2) receptors compared with D2, D4 and D5 (pKi=8.5-8.0) and a 100-fold selectivity compared with D1 receptors (pKi=7.2). In functional studies, Rotigotine behaves as full agonist at all dopamine receptors but notably the potency for stimulation of D1 receptors is similar to that for D2 and D3 receptors (pEC50?respectively: 9.0, 9.4-8.6, 9.7).Rotigotine (10 μM) decreases the number of THir neurons by 40% in primary mesencephalic cell culture. Rotigotine (0.01 μM) slightly protects dopaminergic neurons against MPP+toxicity, significantly protects dopaminergic neurons against rotenone-induced cell death, and significantly inhibits ROS production by rotenone.

——

1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-

GPCR/G Protein

Dopamine Receptor

Dopamine

——

——

92206-54-7

315.47

C19H25NOS

>98% (HPLC)

——

CCCN(CCc1cccs1)C(CC1)Cc2c1c(O)ccc2

——

(-20℃)

With Ice Pack

≥ 2 years